Regarding the fact that FcγR polymorphisms act as genetic risk factor in developing autoimmunity [22] and their roles in SLE development have not yet been identified in the Iranian population, this study was aimed to determine whether two SNPs (rs1050501 and rs396991) in FcγRIIB and IIIA genes may associate with systemic lupus erythematosus disease activity index (SLEDAI) in the Iranian population. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.