Seminal studies in the early 1990’s in the laboratory of Tsunao Saitoh discovered a non-amyloid component in senile plaques (NACP) [17] using biochemical methods, and later showed that NACP was a synaptic protein with genetic locus on chromosome 4q21.3-q22 identical to α-synuclein [18]. The gene discussed is SNCA; the disease is Senile plaques.