In contrast, Beach and colleagues did not detect phosphorylated-α-synuclein histopathology of the abdominal skin and scalp in patients with PD, DLB, incidental Lewy body disease, or Alzheimer’s disease with Lewy bodies, as well as healthy individuals (0% sensitivity and 100% specificity) [180]. Here, SNCA is linked to early-onset autosomal dominant Alzheimer disease.