Numerous studies have demonstrated elevated expression of IL-18, IL-1β, NLRP3, and caspase-1 in the serum, CSF, and leukocytes of patients with active MS, and CSF IL-1β levels correlate with the number and volume of cortical demyelinating lesions, as well as the severity of the disease course [99–103]. Here, IL1B is linked to myeloid sarcoma.