Transfection of circSMARCA5 into the hepatocellular carcinoma cells up-regulated the expression of tissue inhibitor of matrix metalloproteinase 3 (TIMP3) through adsorption of miRNA-17-3p and miRNA-181b-5p, and ultimately inhibited the proliferation, invasion and metastasis of hepatocellular carcinoma cells [18]. The gene discussed is TIMP3; the disease is hepatocellular carcinoma.