TKTL1 and neoplasm: In the metabolic process of many malignant tumors, even under sufficient oxygen supply, they prefer the glycolysis pathway, which consumes more glucose [29].TKTL1 was a key enzyme in the non-oxidative branch of PPP, and its overexpression promoted the formation of nucleic acid, ATP and lactic acid, thus providing a large amount of raw materials for tumor growth [9].