Importantly, in a PCa xenograft mouse model with activation of PI3K-AKT-mTOR pathway, imidazole ketone erastin, a ferroptosis induction agent, alone had no effects on tumor growth, but its combination with Temsirolimus, a mTORC1 inhibitor, resulted in dramatic tumor regression [50]. The gene discussed is PIK3CA; the disease is posterior cortical atrophy.