To further clarify whether the PI3K/AKT pathway mediates the regulatory effect of circIL4R on the aggressive behaviors of CRC cells, 740Y-P, an activator of the PI3K/AKT signaling pathway, and LY294002, an inhibitor of the PI3K/AKT signaling pathway, were used to perform rescue experiments in cells with circIL4R knockdown and overexpression, respectively. The gene discussed is AKT1; the disease is colorectal carcinoma.