TRIM29 and colorectal carcinoma: More importantly, the results of rescue experiments further demonstrated that TRIM29 overexpression reversed the inhibition of functional phenotypes and deactivation of the PI3K/AKT signaling pathway caused by circIL4R knockdown, suggesting that the circIL4R/miR-761/TRIM29 axis facilitated the proliferation and metastasis of CRC cells by regulating the PI3K/AKT signaling pathway.