To explore whether circIL4R could activate the PI3K/AKT signaling pathway and facilitate CRC progression by encoding protein/peptides or binding with specific protein(s), we first searched the circRNADb online database and found no open reading frame (ORF) in the sequence of circIL4R, indicating that no protein features were predicted and that the possibility of encoding protein by circIL4R was relatively low. The gene discussed is AKT1; the disease is colorectal carcinoma.