TFAP2C and colorectal carcinoma: More importantly, we found that TFAP2C induced circIL4R upregulation via transcriptional regulation and that circIL4R overexpression competitively interacted with miR-761 to enhance TRIM29 expression, thereby targeting PHLPP1 for ubiquitin-mediated degradation to activate the PI3K/AKT signaling pathway and facilitate CRC progression, as shown in Fig. 9m and Fig. S3k.