Meanwhile, excess reactive oxygen species (ROS) induce immunogenic cancer cell death (ICD), and promote the secretion of various pro-inflammatory cytokines from immune cells, (e.g., interferon-γ (IFN-γ), interleukin-6 (IL-6), tumor necrosis factor (TNF)), thereby enhancing the inflammatory response in tumor sites for further immune activation [15]. This evidence concerns the gene TNF and neoplasm.