Furthermore, the enriched GO term GO: 0046649 (cellular response to organic substance) contains up-regulated gene FGFR4 and down-regulated genes TIMP3, GAS1 and SPON2. There were pathways focal adhesion, proteoglycans in cancer, regulation of actin cytoskeleton, TGF-beta signaling pathway, pertussis and measles in KEGG enriched results covering genes CXCL12, FGFR4, MYL9, F2R, LPAR1, FGF7 and so on. This evidence concerns the gene TIMP3 and cancer.