Specifically, FOXA1 plays a significant role in non-small cell lung cancer [103], MEF2 family members have a role in lung carcinoma [104, 105], TEAD family members have known roles in carcinogenesis of epithelial tissues [106], and NKX2–1 has a long history of involvement in lung cancer, COPD and IPF [87, 107–110]. The gene discussed is NKX2-1; the disease is non-small cell lung carcinoma.