While using a lung cancer cell line model is not ideal for studying differentiation of normal human cells, it is the only publicly available model of human lung origin where ChIPseq for FOXA1, NKX2–1, and both enhancer marks H3K27Ac and H3K4me1 have been generated with high enough quality for downstream analysis [86, 87]. The gene discussed is FOXA1; the disease is lung cancer.