When nontreated ID8 and MCA205 cells were compared, higher basal levels of antiviral response genes (e.g., Cxcl10, Ifnb, Il1b) and lower basal levels of dsRNA sensor genes (e.g., Ddx58, Tlr3) were observed in MCA205 cells, which would limit viral infection/replication and detection, respectively. This evidence concerns the gene IFNB1 and viral infectious disease.