When nontreated ID8 and MCA205 cells were compared, higher basal levels of antiviral response genes (e.g., Cxcl10, Ifnb, Il1b) and lower basal levels of dsRNA sensor genes (e.g., Ddx58, Tlr3) were observed in MCA205 cells, which would limit viral infection/replication and detection, respectively. The gene discussed is IL1B; the disease is viral infectious disease.