While reovirus alters the TME and drives an increase in the levels of CD3 and CD8 tumor-infiltrating lymphocytes in both the ID8 and MCA205 models, it did so at a much higher level in the ID8 model (Fig. 1, H and I) as compared with the MCA205 model (Fig. 1, J and K). Here, CD8A is linked to neoplasm.