CD274 and Reoviridae infectious disease: Of note, programmed death-ligand 1 (PDL-1), on the other hand, is not upregulated on CD3 and CD8 T cells at the site of infection, despite an initial peak at 1 day post injection, (Fig. 3C) nor on MCA205 cancer cells in response to reovirus infection in vitro (Fig. 3D).