A comparison of the network plot of the DEGs of lung epithelial cells between Nkx2.1Cre; Lkb1f/f and littermate controls showed that the epithelial-derived LKB1-relevant lung diseases were ranked by lung carcinoma, as expected, since LKB1 is known as a tumor suppressor (Fig. 3e). This evidence concerns the gene STK11 and lung disorder.