TM4SF5 and metabolic dysfunction-associated steatohepatitis: Because C57BL/6-TgTM4SF5 mice exhibited nonalcoholic steatohepatitis (NASH)-associated fibrotic livers [24], we determined whether TM4SF5 overexpression in a disease-susceptible mouse strain (i.e., FVB/N [23]) caused an enhanced malignant cancer phenotype.