TM4SF5 and hepatocellular carcinoma: The levels of laminins and pY705STAT3 (Fig. 1E), collagen I, α-smooth muscle actin (SMA), laminins, laminin γ2, and TM4SF5 expression levels were elevated in FVB/N-TgTM4SF5 mice compared with age-matched WT mice, in addition to CD34, AFP, α-l-fucosidase [FUCA (AFU)], which are HCC markers [29–31], hepatic damage, and collagen I deposition (Fig. 1F).