Because C57BL/6-TgTM4SF5 mice exhibited nonalcoholic steatohepatitis (NASH)-associated fibrotic livers [24], we determined whether TM4SF5 overexpression in a disease-susceptible mouse strain (i.e., FVB/N [23]) caused an enhanced malignant cancer phenotype. The gene discussed is TM4SF5; the disease is cancer.