An open-label, prospective study [84] utilising diet and a structured exercise program for three months in 51 obese women with physician-diagnosed moderate to severe asthma showed that, alongside improvements in lung volumes and airflow on exertion, loss of > 5% of body weight had a favourable impact on asthma biomarkers (FeNO), systemic biomarkers (reduced IL-2, IL-4, increased IL-10), and patient-centred outcomes (ACQ, AQLQ). The gene discussed is IL4; the disease is asthma.