In this study, we made several interesting observations: (1) lnc‐GAS5 expression was higher in patients with AIS than in the controls and was a good predictor of AIS risk; (2) lnc‐GAS5 was positively correlated with NIHSS score and pro‐inflammatory cytokine expression (TNF‐α, IL‐6, and IL‐17A), and was negatively correlated with anti‐inflammatory cytokine (IL‐10) in patients with AIS; and (3) lnc‐GAS5 was negatively associated with RFS in patients with AIS. The gene discussed is IL10; the disease is androgen insensitivity syndrome.