In other words, the RUNX1-RUNX1T1 oncoprotein, as the triggering factor, mediates epigenetic inactivation and gene silencing of the UBXN8 gene in t(8;21) AML, which blocks the specific antitumor effect of the UBXN8 gene against t(8;21) AML. The gene discussed is UBXN8; the disease is acute myeloid leukemia.