RUNX1 and acute myeloid leukemia: To address the question of whether the RUNX1-RUNX1T1 oncoprotein mediates UBXN8 epigenetic silencing in t(8;21) AML, we searched the JASPAR database for RUNX1-binding sites (http://jaspar.binf.ku.dk/cgi-bin/jaspar_db.pl) and found two putative RUNX1-binding sites (–1370 to –1360 bp, –921 to –911 bp) at the 5′ end of the predicted “core-promoter” sequence on the UBXN8 promoter region (–1500 to –1 bp) (Fig. 4a).