Among the genes with varied methylation in RUNX1-RUNX1T1+ leukemia cells, UBXN8 has obvious hypermethylation at its promoter region, and evidence from several bioinformatic databases shows that UBXN8 is obviously downregulated in RUNX1-RUNX1T1+ leukemia, which garnered our attention. This evidence concerns the gene RUNX1T1 and leukemia.