We also showed for the first time that hypermethylation of the promoter region of the UBXN8 gene leads to the specific downregulation of UBXN8 expression in RUNX1-RUNX1T1+ leukemia and that the RUNX1-RUNX1T1 oncoprotein can bind to the RUNX1-binding site along the UBXN8 gene promoter sequence; this protein in turn can recruit DNMT3A and DNMT1 to form a complex and methylate CpG islands within the UBXN8 promoter, thus blocking its transcription (Fig. 6f). Here, RUNX1T1 is linked to leukemia.