Having demonstrated the relevance of the RUNX1-RUNX1T1 oncoprotein in the regulation of UBXN8 gene expression and the biological effects of UBXN8 restoration on SKNO-1 cells in vitro, we focused on evaluating whether these findings could provide a potential viable therapeutic target for RUNX1-RUNX1T1+ leukemia in vivo. Here, UBXN8 is linked to leukemia.