Consistent with these results, neutrophil depletion also lead to a reduction of gene expression levels related to liver fibrosis including collagen type 3 (Col3a1: 1.4 ± 0.37 vs. 4.8 ± 0.25; p = 0.0002) and tissue inhibitor of metalloproteinase-1 (Timp-1) (8.2 ± 2.4 vs. 18 ± 1.3; p = 0.001) (Fig. 2e). This evidence concerns the gene TIMP1 and Hepatic fibrosis.