These current results support the findings of a recent report by Zhou et al. in a murine model of combined non-alcoholic and alcoholic steatohepatitis induced by the administration of a high fat diet (HFD) and a binge of ethanol where neutrophils were found to be crucial for the activation of HSCs in part by releasing ROS, while these promoted neutrophil survival via the production of GM-CSF and IL-1527. Here, CSF2 is linked to alcoholic fatty liver disease.