Nakashima et al. demonstrated the important contribution of activated F4/80+ CD11b+ macrophages in a high fat-cholesterol diet-induced hepatitis by enhancing TNF-α production and stimulating the TNF/FasL pathway in NKT cells28, which could be ameliorated by suppressing the recruitment of these cells by the means of neutrophil depletion. Here, TNF is linked to Hepatitis.