The obtained results revealed that PPARδ and miR-17 expressions were able to differentiate macroscopically unchanged lung tissue from NSCLC with AUC-ROC values of 0.914 (95% CI: 0.840–0.989; p = 0.00001) and 0.692 (95% CI: 0.840–0.989, p = 0.0117), respectively. The gene discussed is PPARD; the disease is non-small cell lung carcinoma.