Specifically, T cell populations from Osm−/− tumours expressed higher levels of the co-stimulatory molecule 4-1BB (T_C6), activation markers such as CD44 (T_C8 and T_C4) and CD127 (T_C13), alongside decreased levels of TCRβ (T_C5) (Fig. 5g), consistent with improved T cell activation43,44. This evidence concerns the gene OSM and neoplasm.