Further investigating the association between Osmr expression and the iCAF phenotype in vivo, we compared the expression of inflammatory mediators in Osmrpos and Osmrneg CAFs using publicly available scRNA-seq datasets of KPC27 and KPP33 tumours, which revealed elevated expression of Il6, Ccl2, Ccl7 and Cxcl1 in Osmrpos CAFs (Fig. 1g). This evidence concerns the gene CXCL1 and neoplasm.