This is further supported by gene expression analysis, where CAFs isolated from Osm−/− tumours exhibited decreased inflammatory gene expression (e.g. Il6, Mmp3, Has2 and Osmr) but increased myofibroblast gene expression (e.g. Acta2, Itgav and Fn1) (Fig. 5d left). The gene discussed is OSMR; the disease is neoplasm.