While comprehensive analyses are missing on AP patients with hypoalbuminemia and albumin loss in AP, we aimed to evaluate (1) on-admission and in-hospital hypoalbuminemia as a risk factor in AP, (2) the prognostic potential of human serum albumin, (3) whether there is a dose-dependent relationship between albumin level and disease outcomes and (4) the relation of albumin loss to severity and mortality. Here, ALB is linked to Hypoalbuminemia.