Conversely, adenoviral delivery of LIFR not only reduced the growth of AKT- and Ras-induced HCC but also sensitized these tumors to sorafenib treatment, as gauged by the liver weight, the liver-to-body weight ratio, and bioluminescent imaging (Fig. 2h, i and Supplementary Fig. 4); these effects were abrogated by co-treatment with the ferroptosis inhibitor liproxstatin-140,44 (Fig. 2h, i and Supplementary Fig. 4). This evidence concerns the gene LIFR and hepatocellular carcinoma.