Moreover, electron microscopy analysis revealed that in PDX line #5, tumor cells from the combination treatment group contained shrunken mitochondria with heavily condensed membrane, a morphologic feature of ferroptosis17,40; sorafenib or anti-LCN2 treatment alone also increased membrane density of mitochondria, but to a lesser extent than their combination (Fig. 7c). This evidence concerns the gene LCN2 and neoplasm.