LCN2 and hepatocellular carcinoma: Conversely, Lcn2 was downregulated in LIFR-overexpressing PHM cells (Supplementary Fig. 5f, g); in an oncogene-induced HCC model, adenoviral delivery of LIFR decreased p65 phosphorylation (Supplementary Fig. 5h) and Lcn2 proteins levels (Fig. 3p, q) in liver tissues, and reduced levels of secreted Lcn2 in the serum (Supplementary Fig. 5i, j).