Strikingly, either p65 shRNA or Lcn2 shRNA blocked liver tumorigenesis induced by hepatocyte-specific knockout of Lifr (Fig. 4k–m and Supplementary Fig. 5k), suggesting that loss of Lifr promotes liver cancer development through, at least in part, NF-κB and Lcn2. The gene discussed is NFKB1; the disease is liver cancer.