LYAR and cancer: Analogous to previous studies in other cancer types20, we identified four major subtypes of T cells based on marker expression: naive-like T cells (Cluster 3, 5, 7, 8: SELL+, IL7Rhigh, immune checkpoint receptor (ICR)negative/low), cytotoxic T cells [Cluster 1, 4, 5, 11, 12: GNLYhigh, KLRG1+, ICRlow/intermediate] and dysfunctional/exhausted cells (ICRhigh) that are further sub-divided into pre-dysfunctional (Cluster 1, 9, 10: GZMKhigh, CXCL13low, LYAR+) and terminally dysfunctional cells (Cluster 0, 2: GZMKlow, CXCL13high, ENTPD1+) (Supplementary Fig. 3A, B).