CD274 and neoplasm: In 4/5 patients tested, PD-L1+ macrophages closely associated with CD8+ and CD8− T cells in both tumor (median distance across all patients of 19.6 and 21.5 μm, respectively) and stromal regions (median distance across all patients of 13.2 and 16.9 μm, respectively; Fig. 8E; Supplementary Fig. 12B).