Cancer cells from lesions with high infiltration showed significant enrichment of epithelial-to-mesenchymal transition (EMT), MYC targets, IFNγ response, mitotic spindle formation, and allograft rejection gene programs (−log(10)p-value 4.8, 4.8, 3.7, and 3.7, respectively), while cells from a micro-milieu with low infiltration displayed significantly enriched P53 pathway, fatty acid metabolism, glycolysis and hypoxia gene sets (−log(10)p-value 8.5, 4,2, 3.7, and 3.7, respectively). Here, TP53 is linked to cancer.