Moreover, other disease-associated proteins such as NDE-like 1 (NDEL1) and lissencephaly 1 (LIS1), whose impaired function results in microcephaly and lissencephaly, respectively, interact with these regions [26] alongside the motor protein dynein, all of these being crucial for mitosis. The gene discussed is PAFAH1B1; the disease is lissencephaly spectrum disorders.