RPRD1A and hepatocellular carcinoma: As expected, two independent shRNA sequences targeted RPRD1A (shRPRD1A) markedly suppressed HCC cell proliferation in vitro (Fig. 2A, B and Fig. S1B, S1C), while overexpression of RPRD1A increased cell proliferation (Fig. 2C, D and Fig. S1D, S1E).