The median RIPK3 levels were raised in a step-wise manner from 6248 pg/mL (interquartile range [IQR], 3760–9773) in AD, to 10,200 pg/mL (IQR, 6858–17152) in ACLF grade 1, and finally 20,981 pg/mL (IQR, 9296–38,877) in ACLF grade 2/3 (p < 0.001 for overall comparison) (Table 2, Fig. 1A). The gene discussed is RIPK3; the disease is Alzheimer disease.