MYC and colonic neoplasm: In this context, we conducted this research to investigate the mechanism of OLR1/c-MYC/SULT2B1 axis in chemoresistance of colon cancer, and uncovered that knockdown of OLR1 could downregulate c-MYC to diminish the transcription of SULT2B1, thus repressing glycolytic metabolism and then reducing the proliferation and chemoresistance of colon cancer cells (Fig. 8).