SMAD4 and malignant colon neoplasm: Furthermore, the sensitivity of LoVo colon cancer cells to DDP, oxaliplatin, 5-Fu, and paclitaxel was distinctly enhanced, P-gp expression was authentically declined, and SMAD4 expression was noticeably augmented subsequent to OLR1 knockdown, which was reversed by further overexpressing c-MYC (Fig. 3E, F).