From RT-qPCR result, OLR1 and c-MYC mRNA expression was obviously diminished in OLR1-silenced colon cancer cells, while in the presence of sh-OLR1, elevated c-MYC mRNA expression was observed in colon cancer cells after further oe-c-MYC treatment (Fig. 3A). Here, MYC is linked to malignant colon neoplasm.