By analyzing the clinical data (COADREAD) of colon cancer in TCGA database through GEPIA, the relationship between these 12 genes and survival of colon cancer was obtained, which found that only SULT2B1 and GDF15 were certainly correlated with survival, and the correlation of SULT2B1 was significantly higher than that of GDF15 (Supplementary Table 3 and Fig. 4B). This evidence concerns the gene GDF15 and colonic neoplasm.