As reflected by RT-qPCR, increased c-MYC and SULT2B1 expression in LoVo colon cancer cells was noticed following c-MYC overexpression, which was opposite after silencing c-MYC (Fig. 4D), indicating that c-MYC could upregulate SULT2B1. This evidence concerns the gene SULT2B1 and colonic neoplasm.