In line with these findings, TSLP treatment ameliorated atherosclerosis in the ApoE knockout mouse model by a dendritic and regulatory T cell-mediated mechanism suggesting that TSLP might regulate cholesterol metabolism in addition to lipid metabolism in adipose tissue as shown in the study by Choa et al. This confirms a more general impact of TSLP on the involvement of immune cells in the regulation of lipid metabolism.2 The gene discussed is TSLP; the disease is atherosclerosis.