TSLP and metabolic syndrome: Interestingly, expression was lower in obese men with metabolic syndrome compared with those without metabolic syndrome indicating an association of TSLP with whole-body energy homeostasis.3 The common regulation of TSLP expression in adipose tissue and sebum production in sebocytes by TSH may thus suggest a functional link between the regulation of body energy balance and utilization of adipose-derived lipids in sebum production by a feed-forward mechanism.