IGHE and urticaria: Recurrent urticaria was noted, and laboratory tests revealed the following: total serum immunoglobulin E (IgE) of 16 IU/mL; total complement level within normal limits; undetectable serum IgE for insect venoms, tuna, and crab; undetectable autoantibodies to nuclear antigen (ANA); a negative recommended avoidance of all seafood.