Accordingly, to analyse the protective and pathogenic potential DRD3-signalling in B cells in CNS autoimmunity, we used two EAE models, which differ in the nature of the autoantigen and display differential B-cell involvement: (i) the EAE model independent of the APC-function of B cells, which is induced by immunization with pMOG; and (ii) the EAE model dependent of the APC-function of B cells, which is induced by immunization with huMOG. Here, DRD3 is linked to Autoimmunity.