Mouse models of CRC have significant differences with human, as well as the method of CRC induction usually involves either chemical (i.e., 1,2‐dimethylhydrazine) treatment or pan‐colonic Apc knockout which is starkly different from human sporadic CRC tumorigenesis which likely arise from random mutation events of a single initiating cell [55, 56]. This evidence concerns the gene APC and colorectal carcinoma.