SNCA and Parkinson disease: These findings are in line with previous reports of Parkinson’s disease-associated mutations in α-synuclein promoting Lewy body formation in DaNs65 and with studies suggesting a role for LRRK2 mutations in the activation of microglia in Parkinson’s disease.66 Lastly, we investigated which pathways are associated with the Parkinson’s disease variant enrichment in DaNs and microglial differentially expressed genes (Fig. 5C and D).