CADPS2 has previously been linked to catecholamine uptake and genetic Parkinson’s disease.67–69 In addition, elevated levels of TIAM1, which is involved in Wnt/Dvl/Rac1 signalling,47,48 made us wonder whether CADPS2high cells constitute degenerating DaNs that have lost their dopaminergic identity. Here, RAC1 is linked to Parkinson disease.