The kinase LRRK2 is most abundant in immune cells and may contribute to inflammasome formation via the phosphorylation of Rab GTPases.72 In line with this finding, Parkinson’s disease risk variant enrichment analysis in microglial differentially expressed genes highlighted the kinase activity and NLRP3 inflammasome pathways. The gene discussed is NLRP3; the disease is Parkinson disease.