Aberrant dopamine function in metabolically impaired but viable neurons in the SN has previously been observed in Parkinson’s disease post-mortem tissue.70 Corroborating our hypothesis, CADPS2 quantification in neuromelanin-positive DaNs isolated from midbrain tissue of two scRNA-sequenced samples (C1 and IPD4) and four additional idiopathic Parkinson’s disease patients and four new control subjects revealed higher levels of CADPS2 in the former cells. This evidence concerns the gene CADPS2 and Parkinson disease.