It has been shown the Kelch-like ECH-associatedprotein 1 (Keap1)-Nrf2-ARE has a critical function in the antioxidantresponse of cells.101 AXT antioxidant mechanismsadditionally include regulating the PI3K/Akt signaling pathway.110 AXT acting as a shield for photoreceptor cellsfrom oxidative stress reduced apoptosis due to stimulation of thePI3K/Akt/Nrf2 signaling pathway at hyperglycemia conditions. The gene discussed is AKT1; the disease is Hyperglycemia.