ITK and graft versus host disease: A higher proportion of Itk–/– Tregs also expressed CXCR3 compared to WT Tregs regardless of canonical or noncanonical status (Figure 2I; Figure S5A), suggesting that both canonical and noncanonical Itk–/– Tregs may have better suppressive ability in attenuating acute GVHD compared to canonical or noncanonical Tregs from WT mice.