Since approximately 51% of glioma are mutated for p53, we included two glioma cell lines with different p53 status, U87MG with wild-type p53, and T98G with a gain-of-function M237I mutation (Van Meir et al., 1994), to dissect common mechanisms of the role of NMNAT in glioma cell growth. The gene discussed is TP53; the disease is central nervous system cancer.