TP53 and central nervous system cancer: As both PARylation and deacetylation modifications of p53 have been reported to inactivate p53-mediated function and activity (Juan et al., 2000; Luo et al., 2000; Malanga et al., 1998; Simbulan-Rosenthal et al., 1999), collectively, our results suggest a model where NMNAT promote glioma growth through facilitating NAD+-dependent PTMs of p53 to ameliorate apoptosis (Figure 11E).