Most genes were found to be closely related to various pathways, such as the ErbB signaling pathway, PD-1 checkpoint pathway, and GnRH signaling pathway, all of which are involved in the progression of RA.[44–46] In addition, considering the vital role of immune cell infiltration in RA, the CIBERSORT algorithm method was further applied. This evidence concerns the gene GNRH1 and rheumatoid arthritis.