NFKB1 and rheumatoid arthritis: Moreover, NFkB has been also involved in dendritic, B and T cell activation,[17] and B cells play an important role in RA, because of the production of anti-CCP antibodies.[32] Therefore, the association of the rs28362491 polymorphism in the NFkB gene with anti-CCP antibody levels observed could be explained through the influence of the NFkB on IL-6 production, non-specific citrullination and B cell activation.