The uncontrolled activation of the NFkB signaling pathway has been involved in promotion of the inflammatory response in different autoimmune disease.[14–17] The association of the rs28362491 in the NFkB gene with RA has been reported by different groups with contradictory results,[18–20] in where the minor allele appears to be dependent of the studied population, and the association of this polymorphism on the clinical features, such as DAS28 and HAQ-DI, have showed also different results. The gene discussed is NFKB1; the disease is autoimmune disease.