TNF and cancer: RA is a multifactorial autoimmune disease characterized by a chronic inflammatory process[7] in which cytokines such as TNFα, IL-1, and IL-6 are involved and induce activation of the NFkB transcription factor.[11,23] The NFkB -94 Ins/Del ATTG polymorphism (rs28362491) has been associated with various inflammatory diseases, including cancer[24] and several autoimmune diseases.[25]