Signal transduction pathways provide an intracellular mechanism through which cells respond and adapt to environmental stress.[8] One of the intracellular signaling pathways that shows high activity in RA synovial joints is the nuclear factor kappa B (NFkB), which is involved in regulating proinflammatory cytokine production.[9] The NFkB family plays a central role in inflammation because its members can induce the expression of various proinflammatory cytokines.[10,11]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.