Longitudinal studies in patients with T2D demonstrated a predictive effect of FGF21 on the progression of kidney diseases, represented as eGFR decline to new stages of CKD[6] or new onset of diabetic nephropathy.[7] A study conducted in 1700 Asian patients with T2Dfollowed for a mean of 6.3 years only found an association between FGF21 and end-stage renal disease in women. Here, FGF21 is linked to type 2 diabetes mellitus.