In doubt of diagnosis, a puncture to the cyst can be performed to indicate a chyle-like liquid composed of 90% to 100% lymphocytes and rich in triglycerides.[3,17] When the cyst is removed, immunohistochemical analysis can show CD31 CD34 factor VIII and keratin positivity which are biomarkers of the epithelial and endothelial nature of a wall vessel, thus removing any doubt about cancer or a lymphocele.[4,7,12,15,22] Complications can occur when cysts become permanent and cause compression of the surrounding anatomical structures.[7,9,10]. Here, PECAM1 is linked to cancer.