Defects in the SFTPC gene were first reported by Nogee et al in 2001.[10] SFTPC is located on chromosome 8p21 and encodes SP-C, a hydrophobic 35-amino acid polypeptide secreted into the alveolar space by alveolar type II epithelial cells to facilitate reductions in surface tension.[11] SP-C mutations are thought to be the cause of various lung diseases in patients of different ages. Here, SFTPC is linked to lung disorder.