ABCA3 and lung disorder: Surfactant protein B, surfactant protein C (SP-C), and ATP-binding cassette 3 (ABCA3) are important components of pulmonary surfactants.[6] Although pulmonary surfactant proteins account for a small proportion of surfactant composition, they play important roles in surfactant homeostasis.[7,8] Additionally, pathogenic variants in genes encoding surfactant protein B and ABCA3, transmitted by recessive traits in newborns, can cause severe, fatal lung disease.[9]