ABCA3 and Failure to thrive: The typical presentation of SP-C mutations include dyspnea, cough, or wheezing with an onset between 2 and 12 months of age, as well as gradual cyanosis and failure to thrive.[12–14] Additionally, children with SFTPB mutations have acute onset and severe phenotypes,[15] and ABCA3 mutation phenotype is more variable and lethal.[16] The presentation of SP-C dysfunction varies widely both in terms of the time of onset and the disease severity.[17]