Functional studies show that BRICHOS mutations mainly lead to misfolding and abnormal processing of SP-C precursor proteins, leading to endoplasmic reticulum stress, while non-BRICHOS mutations affect the directed transport of SP-C protein within the cell.[21,22] In our study, mutation including c.547T > C existed in SP-C gene was discovered in RDS infant. This evidence concerns the gene SFTPC and newborn respiratory distress syndrome.