PTOV1 and Familial prostate cancer: Prostate tumor overexpressed-1 (PTOV1) is a 46 kDa protein with a tandem duplication of 2 repeated homology blocks of the sequence of 151 and 147 amino acids closely related to each other, located on the 19q 13.3–13.4 chromosome.[1] PTOV1 was first identified while screening the genes whose overexpression is made in prostate cancer, which is involved in prostate cancer progression.[2,3] As an adaptor, PTOV1 is conserved in vertebrates (mammals and fish) and arthropods (insects).