XRCC1Arg399Gln non-synonymous mutations cause amino acid sequence changes that affect protein function and DNA repair ability, and may affect the interaction with other DNA repair proteins, leading to an increased risk of tumor.[55] Wu[56] detected XRCC1 mRNA expression in peripheral blood of patients with ovarian cancer in the platinum sensitive group (19 cases), part of the platinum sensitive group (25 cases) and the platinum resistant group (22 cases). This evidence concerns the gene XRCC6P5 and ovarian carcinoma.