For that purpose, group of 45 children with obesity (OB) and group of 45 age‐matched children without obesity (CG) were examined in terms of serum levels of miR‐27a and biochemical parameters: fasting blood glucose, adiponectin, leptin, resistin, subfatin, visfatin, and TNF‐α, IL‐6. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.