miR‐196a could reverse the MSC osteogenic differentiation obtained in osteoporosis mice by targeting GNAS to further activate Hh signalling,22 whereas miR‐467g was found to be an inhibitor for osteoblast differentiation, and could negatively regulate the osteogenesis process via Ihh/runt‐related transcription factor 2(RUNX2) signalling.23 Here, GNAS is linked to osteoporosis.