RUNX2 and osteoporosis: Also, Ihh‐Ptch1 signalling was verified to have an important function in postnatal bone homeostasis because Ptch1‐deficient (Ptch+/‐) cells demonstrated augmented osteoblast differentiation, as verified by up‐regulated expression of RUNX2, indicating that Ptch1 may represent a promising modulatory target for osteoporosis treatment.25