Author contributions: S.H., S.X.Z., and H.L. designed experiments and composed the manuscript; S.H. and B.C. performed experiments and acquired the data; J.W. and Y.Z. contributed to the animal study and protocol; O.S. and E.L. provided critical information on p53 mutations in prostate cancers; S.H., B.C., and S.X.Z. contributed to methodology development; Y.X. partly mentored S.H. The project was primarily operated by S.H. under supervision of S.X.Z. and H.L.; B.C., O.S., and S.X.Z. contributed to editing and proofreading of the manuscript; S.H. and H.L. drafted and revised the manuscript. The gene discussed is TP53; the disease is prostate cancer.