Strikingly, our further analysis of publicly available data sets (Cerami et al., 2012; Gao et al., 2013) revealed 40 more cases of this type of p53 mutations with an extended C-terminus across a variety of human cancers, most of which are heterozygous with a wt TP53 allele in the same tumor (Supplementary Figure S1). Here, TP53 is linked to neoplasm.