Interestingly, SOD1 showed interaction with OPTN involved in neuroinflammation, autophagy, and vesicular trafficking in ALS (Maruyama et al., 2010), FTD (Hortobagyi et al., 2011), Alzheimer’s disease, and Huntington’s disease (Schwab et al., 2012). Here, SOD1 is linked to early-onset autosomal dominant Alzheimer disease.