The proteins of module-2 (PSME2, PSMA6, ELAVL1, YWHAQ) and module-4 (OPTN, PSMC2, PSMA2, PSMC6, BANF1) are enriched with RNA processing and protein homeostasis whose disrupts function observed in ALS (Butti and Patten, 2018, Mejzini et al., 2019). This evidence concerns the gene PSMA6 and amyotrophic lateral sclerosis.