In module-2, five proteins (PSMD1, DDX5, PCBP1, ELAVL1, and HNRNPK) were interacting with both CDC5L and TP53 which are functionally enriched with mRNA splicing mechanism which is known to be highly affected in ALS (Butti and Patten, 2018). Here, PSMD1 is linked to amyotrophic lateral sclerosis.