TP53 and amyotrophic lateral sclerosis: In module-2, five proteins (PSMD1, DDX5, PCBP1, ELAVL1, and HNRNPK) were interacting with both CDC5L and TP53 which are functionally enriched with mRNA splicing mechanism which is known to be highly affected in ALS (Butti and Patten, 2018).