Interestingly, SOD1 showed interaction with OPTN involved in neuroinflammation, autophagy, and vesicular trafficking in ALS (Maruyama et al., 2010), FTD (Hortobagyi et al., 2011), Alzheimer’s disease, and Huntington’s disease (Schwab et al., 2012). This evidence concerns the gene OPTN and early-onset autosomal dominant Alzheimer disease.