OPTN and amyotrophic lateral sclerosis: The proteins of module-2 (PSME2, PSMA6, ELAVL1, YWHAQ) and module-4 (OPTN, PSMC2, PSMA2, PSMC6, BANF1) are enriched with RNA processing and protein homeostasis whose disrupts function observed in ALS (Butti and Patten, 2018, Mejzini et al., 2019).