CD4 and neoplasm: Combined with the study showing that CD95 expression in TNBC cells exerts an inhibitory effect on the anti-tumor activity of NK cells, this work raises the question of whether the CD95-dependent p105 ubiquitination and the downstream inhibition of NF-κB are responsible for the general increase in trafficking of macrophages, T cells (CD4+ and CD8+), and NK cells observed in CD95 k.o. TNBCs when compared with parental tumors or whether this mechanism accounts for a more subtle and selective effect on certain immune cells.