KLF2 and Alzheimer disease: Numerous microRNAs (miRNAs) have been considered as key players in the regulation of neuronal processes, e.g. studies as explored by Quang et al., 2018, ameliorate that miR-25 may suppress Kruppel-like factor 2 (KLF2) and stimulate the nuclear factor- E2-related factor 2 (Nrf2) pathway, which further aggravates hippocampal neuron injuries induced by Aβ1-42 in mice with AD [14].