Although circulating miRNA levels were assessed recently in younger patients with T1D and correlated positively with the variations in cytokine levels as measures of immune-mediated signaling pathways proceed in the pathogenesis of diabetes [50–52], little is known about the potential role of miRNAs and its association with myokines and osteopontin (OPN) levels in older patients with type 2 diabetes. Here, SPP1 is linked to type 2 diabetes mellitus.