SPP1 and type 2 diabetes mellitus: In addition, our results for both T2D diabetic groups showed that expressed levels of miR-146a and miR-144 correlated positively with myokines, adropin and irisin, and negatively with HbA1c levels, OPN, and cytokines IL-6, IL-8, IL-18, IL-1β, TNF-α, and serum CRP levels, respectively.