We also found that the expression of these ICI factors was significantly positively correlated with the expression of seven key mRNAs (ANLN, CFL2, ITGA5, KIF23, NFIA, PTX3, and RELT), whereas the expression of immunosuppressive molecules was negatively associated with TMC7 expression, especially in HPV-positive HNSCC patients (Figure 8(f)). The gene discussed is RELT; the disease is head and neck squamous cell carcinoma.