In fact, some papers suggested that beta-adrenergic blockers may be associated with beneficial effects during the acute COVID-19 infection by decreasing the SARS-CoV-2 virus entry, inhibiting NLRP3 inflammasome, reducing IL-6 and so that decreasing the consequent cardio-vascular and pulmonary acute COVID-19 complications (29). This evidence concerns the gene IL6 and COVID-19.